abstract：:In the thesis of the Irish physician Bernard Connor (1666-1698) from 1693 in Rheims he describes the torso of a man whose bones were joined together due to ankylosing spondylitis which is considered to be the first example of such skeletal findings. This communication must however be seen in connection with earlier an...

journal_title：Zeitschrift fur Rheumatologie

authors： Keitel W

更新日期：2012-06-01 00:00:00

abstract：:The assessment of off-label medications is one of the most common reasons for assessment of drugs for individual patients in the German medical services. Tension is not uncommon because of great expectations of patients and doctors on the one hand and the requirements of the law on the other. They often do not match. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Grell L,Rieger M

更新日期：2012-02-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is a mainstay in musculoskeletal imaging. The term"bone marrow edema" is frequently used for describing the radiological findings, especially with respect to rheumatic diseases. The referring physician should be aware that this term has a purely descriptive character and the pathophysi...

journal_title：Zeitschrift fur Rheumatologie

authors： Hamer OW,Kriegsmann J

更新日期：2012-01-01 00:00:00

abstract：:The nephrotoxicity of methotrexate (MTX) is a phenomenon which is observed in high-dose therapy for treatment of malignant diseases. Even low-dose MTX therapy for treatment of rheumatic diseases is claimed to cause impairment in renal function. The necessity to adapt the dosage of MTX therapy for renal function disord...

journal_title：Zeitschrift fur Rheumatologie

authors： Fiehn C

更新日期：2011-12-01 00:00:00

abstract：:The international treat-to-target initiative including rheumatoid arthritis (RA) patients has defined remission or alternatively low disease activity as treatment goals. In Germany representatives of the medical profession, such as doctors, nurses and including the Deutsche Rheuma-Liga, are deliberating how to adapt a...

journal_title：Zeitschrift fur Rheumatologie

authors： Gromnica-Ihle E,Rink M

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Recent data provided evidence on the implication of the adipocytokines adiponectin, visfatin, and resistin in inflammation, immune response, and tissue destruction and revealed several links between them and arthritis. AIM OF THE STUDY:The purpose of this study was to assess the levels of adiponectin, visfa...

journal_title：Zeitschrift fur Rheumatologie

authors： Alkady EA,Ahmed HM,Tag L,Abdou MA

更新日期：2011-09-01 00:00:00

abstract：:MicroRNAs are small non-coding RNAs which are crucial for the fine regulation of gene expression. Recent results suggest that these molecules display multifaceted functions in B-cells and T-cells in rheumatic inflammatory diseases. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Wittmann J,Jäck HM,Mashreghi MF

更新日期：2011-08-01 00:00:00

abstract：:This review presents data on morbidity and mortality in patients with spondyloarthritis (SpA). Morbidity in patients with SpA is mainly determined by impairment of function and development of structural lesions. The course of illness in patients with ankylosing spondylitis (AS) is influenced by comorbidities, such as ...

journal_title：Zeitschrift fur Rheumatologie

authors： Kiltz U,Sieper J,Braun J

更新日期：2011-08-01 00:00:00

abstract：:Various rheumatic symptoms can occur in association with malignancies and are termed the so-called paraneoplastic arthropathy. The clinical picture is often similar to primary inflammatory rheumatic diseases. At present there exist no epidemiological data on this disease entity. The case of a patient with tibial pain ...

journal_title：Zeitschrift fur Rheumatologie

authors： Lange U,Bachmann G,Müller-Ladner U

更新日期：2011-06-01 00:00:00

abstract：:The modified significance of radiological criterion in the new ACR/EULAR classification criteria for rheumatoid arthritis is based on the fact that the bone erosion seen using conventional radiology is the result of an already longstanding inflammatory process.In contrast, new imaging modalities such as magnetic reson...

journal_title：Zeitschrift fur Rheumatologie

authors： Strunk J

更新日期：2011-04-01 00:00:00

abstract：:Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying an...

journal_title：Zeitschrift fur Rheumatologie

authors： Keysser G

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The choice between outpatient and inpatient care is currently undergoing major changes within the German health care system with the amendment of § 116b SGB V. This study investigates what proportion of hitherto inpatient rheumatologic care could potentially be given on an outpatient basis. METHODS:The anal...

journal_title：Zeitschrift fur Rheumatologie

authors： Rath T,Bokern E,Sefo-Bukow E,Büscher G,Lüngen M,Rubbert-Roth A

更新日期：2011-01-01 00:00:00

abstract：:Osteoporosis is an age-related systemic disease leading to increased bone fragility. The vertebral bodies of the transitional area between the thoracic and lumbar spine are often involved. A large number of unreported or late-diagnosed fractures have to be assumed. If risk factors such as advanced age or comorbidities...

journal_title：Zeitschrift fur Rheumatologie

authors： Boluki D

更新日期：2011-01-01 00:00:00

abstract：:The "German Society of Rheumatology" was founded in Bad Neuenahr in the Federal Republic of Germany In 1947. The society perceived itself as the successor to the "German Society for the Abatement of Rheumatism". The primary aim of the society was close cooperation with other German-speaking rheumatological societies i...

journal_title：Zeitschrift fur Rheumatologie

authors： Hewelt T

更新日期：2011-01-01 00:00:00

abstract：:Musculoskeletal ultrasonography (US) is an established and validated imaging technique in rheumatology. Ultrasonography is able to directly visualize soft tissue pathologies such as synovial tissue changes. Pathological findings in superficial cartilage, bone lesions and synovial tissue changes in the context of rheum...

journal_title：Zeitschrift fur Rheumatologie

authors： Tamborrini G,Backhaus M,Schmidt W,Ziswiler HR

更新日期：2010-12-01 00:00:00

abstract：:The immune system is regulated by a variety of mechanisms that prevent overwhelming immune responses and a break in tolerance. There have been indications for some time that populations of B cells are also a part of this network and able to exert regulatory functions. Here we summarize current knowledge on this previo...

journal_title：Zeitschrift fur Rheumatologie

authors： Tretter T,Lorenz HM

更新日期：2010-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased mortality, largely as a consequence of cardiovascular (CV) disease. Studies found relative risk ratios of 2 for myocardial infarction in RA and up to 7 for myocardial infarction in SLE patients.Beyond the traditional CV risk...

journal_title：Zeitschrift fur Rheumatologie

authors： Fischer-Betz R,Halle M,Schneider M

更新日期：2010-10-01 00:00:00

abstract：:Certolizumab pegol is a new anti-TNF-alpha inhibitor which has been approved for the treatment of rheumatoid arthritis since October 2009. Due to the modification of the antibody fragment by the adherence of polyethylene glycol (PEG) a sufficient distribution in inflammatory tissue was found in animal experiments. In ...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmeiser T,Müller-Ladner U

更新日期：2010-09-01 00:00:00

abstract：:Inflammatory rheumatic diseases often affect females of childbearing age and pregnancy remains a challenge for this group of patients and their physicians. However, the majority of patients can now have successful pregnancies and deliver healthy babies as a result of our improved knowledge of the risks encountered dur...

journal_title：Zeitschrift fur Rheumatologie

authors： Fischer-Betz R,Gromnica-Ihle E

更新日期：2010-09-01 00:00:00

abstract：:Tocilizumab, a monoclonal humanized antibody against IL-6, was licensed in January 2009 in combination with Methotrexate for the treatment of adult patients with moderately to severely active rheumatoid arthritis and inadequate response to one or more DMARDs or TNF antagonists. Tocilizumab is given once every 4 weeks ...

journal_title：Zeitschrift fur Rheumatologie

authors： Roll P,Rubbert-Roth A,Tony HP

更新日期：2010-09-01 00:00:00

abstract：:Autoimmune hemolysis is a rare complication of systemic rheumatic diseases. We report on a 68-year-old female patient with established, long-standing rheumatoid arthritis, who complained of progressive weakness and worsening of her arthralgia under therapy with leflunomide. Physical and laboratory examination revealed...

journal_title：Zeitschrift fur Rheumatologie

authors： Lehmann P,Hartung W,Ehrenstein B,Schölmerich J,Fleck M

更新日期：2010-08-01 00:00:00

abstract：:Primary osteoarthritis (OA) of peripheral joints is a common disease mainly occurring after the age of 50. It is important to distinguish primary from secondary OA. Younger age at disease onset, rapid progression, unusual disease manifestations and co-morbidities are signs of secondary OA. This review outlines an impo...

journal_title：Zeitschrift fur Rheumatologie

authors： Zwerina J,Dallos T

更新日期：2010-05-01 00:00:00

abstract：:In order to measure therapeutic effects or assess disease course, outcomes measurement parameters are commonly used in patients with rheumatoid arthritis. From the patient's perspective, possibly the most important outcome measurement parameter is quality of life (QoL). QoL may be defined in terms of "health status" a...

journal_title：Zeitschrift fur Rheumatologie

authors： Stamm T

更新日期：2010-05-01 00:00:00

abstract：:The evidence-based recommendations on the management of ankylosing spondylitis (AS) have enjoyed a high level of acceptance and circulation in Germany, as well as in other European countries. To make patient participation in the decision-making process regarding their disease easier, as well as to strengthen the physi...

journal_title：Zeitschrift fur Rheumatologie

authors： Kiltz U,Feldtkeller E,Braun J

更新日期：2010-03-01 00:00:00

abstract：:The name of Sir Alfred Baring Garrod is linked with the first detection of uric acid in blood and its accumulation in sufferers from gout as well as the formulation of the term rheumatoid arthritis. The disease concept formulated by him initially (especially in Germany) caused confusion and much discussion but has now...

journal_title：Zeitschrift fur Rheumatologie

authors： Keitel W

更新日期：2009-12-01 00:00:00

abstract：:Osteoporosis is defined by decreased bone strength and increased susceptibility to fracture. Fractures and their consequences are the clinical manifestation of osteoporosis. Acute and chronic pain, functional limitations including permanent impairment and the need for long-term care may be caused by osteoporotic fract...

journal_title：Zeitschrift fur Rheumatologie

authors： Preisinger E

更新日期：2009-09-01 00:00:00

abstract：:The aim of this review is to critically analyze the evidence of therapeutic ultrasound between 0.8 and 3 MHz for treating musculoskeletal diseases. Relevant randomized, controlled, clinical trials and systematic reviews published on this topic have been taken into consideration.There was evidence of effectiveness for ...

journal_title：Zeitschrift fur Rheumatologie

authors： Ebenbichler G

更新日期：2009-09-01 00:00:00

abstract：:In recent years, new findings in immunology have been successfully converted to therapeutic principles, in particular for rheumatoid arthritis (RA) and spondylarthritides. The introduction of cytokine blockers in RA using tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 inhibitors presented the first original ...

journal_title：Zeitschrift fur Rheumatologie

authors： Mei H,Dörner T

更新日期：2009-07-01 00:00:00

abstract：:Patients with various kinds of intestinal illnesses sometimes suffer not only abdominal symptoms, but also joint involvement, leading to a reduction in quality of life. Diseases leading to inflammatory joint involvement such as inflammatory bowel disease, Whipple's disease or surgical intestinal bypass, are classified...

journal_title：Zeitschrift fur Rheumatologie

authors： Ronneberger M

更新日期：2009-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease. Standard treatment consists of chronic therapy with antimalarials, glucocorticoids and immunosuppressive/cytotoxic drugs, which is associated with considerable side effects. In contrast, immunoablation of autoreactive immunologic memory follo...

journal_title：Zeitschrift fur Rheumatologie

authors： Alexander T,Arnold R,Hiepe F

更新日期：2009-05-01 00:00:00

abstract：:Cell-based therapeutical approaches are already in clinical use and are attracting growing interest for the treatment of joint defects. Mesenchymal stem and precursor cells (MSC) cover a wide range of properties that are useful for the regeneration process of bone and cartilage defects. The following article is an ove...

journal_title：Zeitschrift fur Rheumatologie

authors： Dehne T,Tschirschmann M,Lauster R,Sittinger M

更新日期：2009-05-01 00:00:00

abstract：:Fractalkine (CX3CL1), so far the only member of the CX3C class of chemokines, and its receptor, CX3CR1, are strongly expressed in the chronically inflamed synovial tissue of patients with rheumatoid arthritis (RA). Due to the specific binding of Fractalkine to its receptor, many proinflammatory reactions involved in t...

journal_title：Zeitschrift fur Rheumatologie

authors： Blaschke S,Müller GA

更新日期：2008-09-01 00:00:00

abstract：:Wegener's granulomatosis, Churg-Strauss syndrome and analgesics intolerance syndrome with polyps demonstrate non-specific manifestations in the head and neck region. These symptoms can often lead to early diagnosis and initiation of the correct therapy. However, symptoms are often ambiguous and many rare differential ...

journal_title：Zeitschrift fur Rheumatologie

authors： Laudien M,Ambrosch P,Till A,Podschun R,Lamprecht P

更新日期：2008-09-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal demyelinating disease of the central nervous system induced by the JC virus. It mainly occurs in immunocompromised patients. Growing interest in rheumatology has arisen from reports of patients with rheumatic diseases suffering from PML. A dire...

journal_title：Zeitschrift fur Rheumatologie

authors： Kneitz C,Wiendl H

更新日期：2008-07-01 00:00:00

abstract：:Arthrosis deformans is a common disease worldwide with a high prevalence among all ethnic groups. All joints may be affected and genetic factors influence the onset of the disease. The main symptoms include pain and increasing immobility over the course of the illness. Treatment in early stages is conservative. In the...

journal_title：Zeitschrift fur Rheumatologie

authors： Rehart S,Lehnert H

更新日期：2008-07-01 00:00:00

abstract：:Patient education is a medical intervention for patients with chronic diseases to increase knowledge of their disease, self-efficacy, self-management and consumer behaviour. The goal is to improve their disease outcome, social participation and quality of life. This article reviews concepts, modalities and knowledge o...

journal_title：Zeitschrift fur Rheumatologie

authors： Genth E

更新日期：2008-05-01 00:00:00

abstract：:Osteoid osteomas are painful bone tumors that usually occur in childhood or adolescence. Despite the small size of the bony lesions osteoid osteomas can cause persistent pain. Pathogenesis has not been completely understood. Remission usually occurs within several months to years. Therefore surgical therapy is not ind...

journal_title：Zeitschrift fur Rheumatologie

authors： Hedrich CM,Fiebig B,Sallmann S,Bruck N,Thielemann F,Hahn G,Heubner G,Gahr M

更新日期：2008-03-01 00:00:00

abstract：:The classical septic bacterial arthritis is a rare event, but can be distinguished by unequivocal signs such as fibrin exudation and neutrophilic masses (pus). For a long time we have been observing an abortive form of bacterial arthritis in biopsies which subsides spontaneously without antibiotic intervention. Only v...

journal_title：Zeitschrift fur Rheumatologie

authors： Meyer-Scholten C,Valeva A,Zorn K,Meurer A,Fassbender HG

更新日期：2008-02-01 00:00:00

abstract：:Sjögren's syndrome is a systemic inflammatory rheumatic disorder of unknown origin with so far inadequate therapy options. Management of Sjögren's syndrome is still primarily palliative using local symptomatic measures, and if appropriate glucocorticoids, NSAIDs and immunosuppressive drugs. New clues to the pathogenes...

journal_title：Zeitschrift fur Rheumatologie

authors： Feist E,Dörner T,Hansen A

更新日期：2007-12-01 00:00:00

abstract：AIM:To gather information about current structures in rheumatologic ambulatory health care in Germany. Based on the results recommendations on future structures will be evaluated. METHODS:Data collection and statistical analysis via a structured 10-page questionnaire answered by members of the German Association of Rh...

journal_title：Zeitschrift fur Rheumatologie

authors： Mittendorf T,Edelmann E,Kekow J,von Hinüber U,Müller-Brodmann W,Graf von der Schulenburg JM

更新日期：2007-11-01 00:00:00